The pick of the games in the RaboDirect Round10 will not take place until Sunday, when second placed Scarlets welcome table-topping Ulster to Llanelli. Ulster are the only team with a 100% winning record still intact, although they were held close in their last two games in Italy, but Scarlets, having claimed the scalp of Munster in Cork last weekend, will be anxious to add another Irish Province to their tally. Ulster have already pulled out a 6 point lead over Scarlets at the top of the table, and should this result go their way could see that gap increase into double figures.
The round starts on Friday night with reigning champions Ospreys, facing Cardiff Blues at Liberty Stadium, where the visitors will need all their skills if they are to overcome the odds and return with the points, something they have only achieved once on Ospreys soil since the regions were formed.
The remaining four games are on Saturday, one in Italy and three in Ireland. Newport Gwent Dragons are the third Welsh Region to visit Stadio Monigo in Treviso this season, and none of them have yet come away with a win.
Zebre, make their first visit to the home of the European champions, Leinster. The Italian outfit lost by the slimmest of margins the last time they played an Irish province , the rearranged game against Ulster, but the RDS in Dublin will be a very hard place to go in search of a maiden win.
Edinburgh Rugby, having defeated champions Ospreys last time out, travel to the west of Ireland to face Connacht at the Sportsground. Always difficult place to visit, Edinburgh have not won in Galway since 2008.
And finally there will be a point to prove at Thomond Park when Munster take on Glasgow Warriors. Both teams were defeated last time out, halting Warriors potential record breaking winning run and leaving Munster just outside the Play-Off zone in 5thspot, so both will be looking for the victory to get back on track.